Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates

Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-4
Main Authors: Allegaert, Karel, Bajcetic, Milica, Atkinson, Andrew, Soldatovic, Ivan, Spriet, Isabel, Smits, Anne, Samardzic, Janko, van den Anker, Johannes N.
Format: Article
Language:English
Subjects:
Age
Blood
Catheter-Related Infections - blood
Catheter-Related Infections - drug therapy
Catheter-Related Infections - pathology
Children & youth
Female
Gestational Age
Humans
Hypothesis testing
Immunoassay
Immunoassay - methods
Infant, Newborn
Infants (Newborn)
Infections
Intensive care
Pediatrics
Pharmacology
Pregnancy
Sepsis
Sepsis - blood
Sepsis - drug therapy
Sepsis - pathology
Studies
Vancomycin
Vancomycin - administration & dosage
Vancomycin - adverse effects
Vancomycin - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n = 400 ) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012–2014, n = 352 ) measurements. The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS).
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/1974972