In vitro evaluation of thermal frontally polymerized thiol-ene composites as bone augments

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2016-08, Vol.104 (6), p.1152-1160
• Main Authors: Totaro, Nicholas P., Murphy, Zachari D., Burcham, Abigail E., King, Connor T., Scherr, Thomas F., Bounds, Christopher O., Dasa, Vinod, Pojman, John A., Hayes, Daniel J.
• Format: Article
• Language: English
• Subjects: Animals; Benzoyl peroxide; Biocompatibility; Biomedical materials; bone cement; Bone cements; Bone Cements - chemical synthesis; Bone Cements - chemistry; Bone Cements - pharmacology; Bone implants; Bone Substitutes - chemical synthesis; Bone Substitutes - chemistry; Bone Substitutes - pharmacology; calcium phosphate; Cement; Composite materials; composite/hard tissue; Fibroblasts - cytology; Fibroblasts - metabolism; frontal polymerization; Hydroxyapatite; Materials research; Materials science; Materials Testing; Mechanical properties; Mice; NIH 3T3 Cells; Osteoconduction; Osteogenesis; Polymerization; Surgeons; Surgery; thiol-ene
• ISSN: 1552-4973; 1552-4981
• DOI: 10.1002/jbm.b.33466

Because of the large number of total knee replacement (TKR) surgeries conducted per year, and with projections of increased demand to almost a million primary TKR surgeries per year by 2030 in the United States alone, there is a need to discover more efficient working materials as alternatives to current bone cements. There is a need for surgeons and hospitals to become more efficient and better control over the operative environment. One area of inefficiency is the cement steps during TKR. Currently the surgeon has very little control over cement polymerization. This leads to an increase in time, waste, and procedural inefficiencies. There is a clear need to create an extended working time, moldable, osteoconductive, and osteoinductive bone augment as a substitution for the current clinically used bone cement where the surgeon has better control over the polymerization process. This study explored several compositions of pentaerythritol-co-trimethylolpropane tris-(3-mercaptopropionate) hydroxyapatite composite materials prepared via benzoyl peroxide-initiated thermal frontal polymerization. The 4:1 acrylate to thiol ratio containing augment material shows promise with a maximal propagation temperature of 160°C ± 10°C, with mechanical strength of 3.65 MPa, and 111% cytocompatibility, relative to the positive control. This frontally polymerized material may have application as an augment with controlled polymerization supporting cemented implants. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1152-1160, 2016.