Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

• Published in: Journal of the American Academy of Dermatology 2016-10, Vol.75 (4), p.698-705
• Main Authors: Wei, Erin X., MD, Qureshi, Abrar A., MD, MPH, Han, Jiali, PhD, Li, Tricia Y., MD, MS, Cho, Eunyoung, ScD, Lin, Jennifer Y., MD, Li, Wen-Qing, PhD
• Format: Article
• Language: English
• Subjects: Adult; age; Age Distribution; Aged; anatomic sites; Carcinoma in Situ - diagnosis; Carcinoma in Situ - epidemiology; Carcinoma in Situ - pathology; Dermatology; epidemiology; Female; gender; Humans; Hutchinson's Melanotic Freckle - epidemiology; Hutchinson's Melanotic Freckle - pathology; Incidence; invasive malignant melanoma; lentigo maligna; Male; melanoma; Melanoma - diagnosis; Melanoma - epidemiology; Melanoma - pathology; melanoma in situ; melanoma screening; Melanoma, Cutaneous Malignant; Middle Aged; Neoplasm Invasiveness - pathology; Neoplasm Staging; occupational cohorts; Prospective Studies; Risk Assessment; Sex Distribution; Skin Neoplasms - diagnosis; Skin Neoplasms - epidemiology; Skin Neoplasms - pathology; United States - epidemiology
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2016.05.011

Background The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features. Objective We sought to determine trends in diagnosis and clinical features of MIS. Methods Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Results MIS incidence increased from 2 to 42 per 100,000 person-year among women, and from 11 to 73 per 100,000 person-year among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on the upper half of the body ( P