The CHIPS Randomized Controlled Trial (Control of Hypertension in Pregnancy Study): Is Severe Hypertension Just an Elevated Blood Pressure?

To determine whether clinical outcomes differed by occurrence of severe hypertension in the international CHIPS trial (Control of Hypertension in Pregnancy Study), adjusting for the interventions of “less tight” (target diastolic blood pressure [dBP] 100 mm Hg) versus “tight” control (target dBP 85...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-11, Vol.68 (5), p.1153-1159
Main Authors: Magee, Laura A, von Dadelszen, Peter, Singer, Joel, Lee, Terry, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E, Menzies, Jennifer, Sanchez, Johanna, Gafni, Amiram, Helewa, Michael, Hutton, Eileen, Koren, Gideon, Lee, Shoo K, Logan, Alexander G, Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G, Moutquin, Jean-Marie
Format: Article
Language:English
Subjects:
Adult
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
Birth Weight
Female
Humans
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - drug therapy
Infant, Newborn
Labetalol - administration & dosage
Logistic Models
Maternal Health
Methyldopa - administration & dosage
Multivariate Analysis
Original
Pre-Eclampsia - diagnosis
Pre-Eclampsia - drug therapy
Pregnancy
Pregnancy Complications, Cardiovascular - prevention & control
Pregnancy Outcome
Premature Birth
Prospective Studies
Risk Assessment
Severity of Illness Index
Stroke - prevention & control
Treatment Outcome
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Summary:To determine whether clinical outcomes differed by occurrence of severe hypertension in the international CHIPS trial (Control of Hypertension in Pregnancy Study), adjusting for the interventions of “less tight” (target diastolic blood pressure [dBP] 100 mm Hg) versus “tight” control (target dBP 85 mm Hg). In this post-hoc analysis of CHIPS data from 987 women with nonsevere nonproteinuric preexisting or gestational hypertension, mixed effects logistic regression was used to compare the following outcomes according to occurrence of severe hypertension, adjusting for allocated group and the influence of baseline factorsCHIPS primary (perinatal loss or high-level neonatal care for >48 hours) and secondary outcomes (serious maternal complications), birth weight
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.116.07862