Preoperative γ-glutamyl transpeptidase to platelet ratio (GPR) is an independent prognostic factor for HBV-related hepatocellular carcinoma after curative hepatic resection

Liver fibrosis and cirrhosis is associated with the prognosis of patients with hepatocellular carcinoma (HCC) after treatment. The γ-glutamyl transpeptidase to platelet ratio (GPR) is reported to predict significant liver fibrosis and cirrhosis. The aim of this study was to investigate the predictiv...

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Published in:Medicine (Baltimore) 2016-07, Vol.95 (27), p.e4087-e4087
Main Authors: Wang, Wan-Li, Zheng, Xing-Long, Zhang, Zhi-Yong, Zhou, Ying, Hao, Jie, Tang, Gang, Li, Ou, Xiang, Jun-Xi, Wu, Zheng, Wang, Bo
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - enzymology
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - virology
Female
gamma-Glutamyltransferase - metabolism
Hepatectomy
Hepatitis B - complications
Humans
Liver Cirrhosis - enzymology
Liver Neoplasms - enzymology
Liver Neoplasms - surgery
Liver Neoplasms - virology
Male
Middle Aged
Neoplasm Recurrence, Local
Observational Study
Platelet Count
Preoperative Period
Prognosis
Propensity Score
Retrospective Studies
Survival Analysis
Treatment Outcome
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Summary:Liver fibrosis and cirrhosis is associated with the prognosis of patients with hepatocellular carcinoma (HCC) after treatment. The γ-glutamyl transpeptidase to platelet ratio (GPR) is reported to predict significant liver fibrosis and cirrhosis. The aim of this study was to investigate the predictive value of preoperative GPR on the recurrence and survival of patients with HCC who underwent curative hepatectomy.A retrospective review of demographics, medical records, and prognosis of patients with hepatitis B virus (HBV)-related HCC was performed. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier method, and the log-rank test was used to analyze differences in recurrence and survival. Univariate and multivariate analyses were used for significance of prognostic factor.A total of 357 patients with HBV-related HCC were included in this analysis. The preoperative GPR was associated with recurrence and survival rates, independent of HCC progression or tumor marker levels, in a multivariate analysis. OS was higher in patients with a GPR
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000004087