Lipid-derived reactive aldehydes link oxidative stress to cell senescence

Genotoxic stress can induce proliferative cells to undergo accelerated senescence, where they remain viable but enter an irreversible cell cycle arrest similar to that of replicative senescence, including characteristic changes in gene expression, metabolism, and cell morphology.1 Even though transf...

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Bibliographic Details
Published in:Cell death & disease 2016-09, Vol.7 (9), p.e2366-e2366
Main Authors: Flor, Amy C, Kron, Stephen J
Format: Article
Language:English
Subjects:
631/337/1427/2566
631/67/1059
631/80/509
631/80/86/2366
Aldehydes
Aldehydes - analysis
Aldehydes - chemistry
and
Antibodies
Biochemistry
Cell Biology
Cell Culture
Cell cycle
Cellular biology
Cellular Senescence
DNA Damage
Gene expression
Immunology
Life Sciences
Lipid Peroxidation
Lipids - chemistry
Metabolism
Models, Biological
news-and-commentary
Oxidative Stress
Senescence
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Summary:Genotoxic stress can induce proliferative cells to undergo accelerated senescence, where they remain viable but enter an irreversible cell cycle arrest similar to that of replicative senescence, including characteristic changes in gene expression, metabolism, and cell morphology.1 Even though transformed and tumor cell lines are considered immortal, they can be induced to undergo accelerated senescence. This extends to tumors in vivo, where ionizing radiation or chemotherapy promotes therapy-induced senescence (TIS). Although it remains controversial whether cancer cell senescence is a desirable outcome of cancer treatment, there is limited evidence to suggest that senescent cells in tumors may have beneficial effects, potentially including stimulation of antitumor immunity.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2016.275