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Surgical immune interventions for solid malignancies
Structured Abstract Background The purpose of this study was to systematically review clinically translatable immunotherapeutic agents that are delivered regionally for solid malignancies. Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respecti...
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| Published in: | The American journal of surgery 2016-10, Vol.212 (4), p.682-690.e5 |
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| container_title | The American journal of surgery |
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| creator | Zeltsman, Masha, DO Mayor, Marissa, MD Jones, David R., MD, FACS Adusumilli, Prasad S., MD, FACS, FCCP |
| description | Structured Abstract Background The purpose of this study was to systematically review clinically translatable immunotherapeutic agents that are delivered regionally for solid malignancies. Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respectively. The search yielded 334 relevant publications, of which 116 manuscripts were included for review after exclusion criteria were applied. Conclusions There has been an increase in the regional administration of cell-based and viral vector-based clinical trials over the last 5 years. Surgical interventions have been developed for intrapleural, intracranial, intraperitoneal, and intratumoral routs of access to enhance the local delivery of there therapies. Multimodality therapies that combine regional immunotherapy with other local and systemic therapies are demonstrating continued growth as the field of immunotherapy continues to expand. |
| doi_str_mv | 10.1016/j.amjsurg.2016.06.008 |
| format | article |
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Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respectively. The search yielded 334 relevant publications, of which 116 manuscripts were included for review after exclusion criteria were applied. Conclusions There has been an increase in the regional administration of cell-based and viral vector-based clinical trials over the last 5 years. Surgical interventions have been developed for intrapleural, intracranial, intraperitoneal, and intratumoral routs of access to enhance the local delivery of there therapies. Multimodality therapies that combine regional immunotherapy with other local and systemic therapies are demonstrating continued growth as the field of immunotherapy continues to expand.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2016.06.008</identifier><identifier>PMID: 27659157</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenoviruses ; Adoptive cell therapy ; Antibodies, Monoclonal - therapeutic use ; Antigens ; BCG Vaccine ; Catheterization ; Clinical trials ; Clinical Trials as Topic ; Colorectal cancer ; Combined Modality Therapy ; Cytokines ; Cytotoxicity ; Dendritic cells ; Gangrene ; Gastric cancer ; Granulocytes ; Humans ; Immune system ; Immunotherapy ; Immunotherapy - methods ; Injections, Intralesional ; Iodine ; Laparoscopy ; Liver cancer ; Lung cancer ; Lymphocytes ; Melanoma ; Mesothelioma ; Metastasis ; Neoplasms - pathology ; Neoplasms - therapy ; Ovarian cancer ; Patients ; Pharmaceutical industry ; Regional immunotherapy ; Studies ; Surgery ; Surgical immunotherapy ; Tumor Microenvironment ; Tumor necrosis factor-TNF ; Tumors ; Vaccines ; Vascular Access Devices ; Vectors (Biology)</subject><ispartof>The American journal of surgery, 2016-10, Vol.212 (4), p.682-690.e5</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 01, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-f364a7e2d75068f47dc87fa2a9fad629aa8cb13bdc858d72c0af3f8fa46729703</citedby><cites>FETCH-LOGICAL-c583t-f364a7e2d75068f47dc87fa2a9fad629aa8cb13bdc858d72c0af3f8fa46729703</cites><orcidid>0000-0002-1699-2046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27659157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeltsman, Masha, DO</creatorcontrib><creatorcontrib>Mayor, Marissa, MD</creatorcontrib><creatorcontrib>Jones, David R., MD, FACS</creatorcontrib><creatorcontrib>Adusumilli, Prasad S., MD, FACS, FCCP</creatorcontrib><title>Surgical immune interventions for solid malignancies</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Structured Abstract Background The purpose of this study was to systematically review clinically translatable immunotherapeutic agents that are delivered regionally for solid malignancies. Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respectively. The search yielded 334 relevant publications, of which 116 manuscripts were included for review after exclusion criteria were applied. Conclusions There has been an increase in the regional administration of cell-based and viral vector-based clinical trials over the last 5 years. Surgical interventions have been developed for intrapleural, intracranial, intraperitoneal, and intratumoral routs of access to enhance the local delivery of there therapies. Multimodality therapies that combine regional immunotherapy with other local and systemic therapies are demonstrating continued growth as the field of immunotherapy continues to expand.</description><subject>Adenoviruses</subject><subject>Adoptive cell therapy</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antigens</subject><subject>BCG Vaccine</subject><subject>Catheterization</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Colorectal cancer</subject><subject>Combined Modality Therapy</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Dendritic cells</subject><subject>Gangrene</subject><subject>Gastric cancer</subject><subject>Granulocytes</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Injections, Intralesional</subject><subject>Iodine</subject><subject>Laparoscopy</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Lymphocytes</subject><subject>Melanoma</subject><subject>Mesothelioma</subject><subject>Metastasis</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Ovarian cancer</subject><subject>Patients</subject><subject>Pharmaceutical industry</subject><subject>Regional immunotherapy</subject><subject>Studies</subject><subject>Surgery</subject><subject>Surgical immunotherapy</subject><subject>Tumor Microenvironment</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Vaccines</subject><subject>Vascular Access Devices</subject><subject>Vectors (Biology)</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUk1v1DAQtRAV3S78BFAkLlyyHdvxRy5FqKKAVIlD4Wx5HXtxSOxiJyv13-NolwK9tNJI1thvnmfmPYReY9hgwPy83-ixz3PabUhJN1AC5DO0wlK0NZaSPkcrACB1yzGcorOc-5Ji3NAX6JQIzlrMxAo1N4XCGz1UfhznYCsfJpv2Nkw-hly5mKocB99Vox78LuhgvM0v0YnTQ7avjucafb_6-O3yc3399dOXyw_XtWGSTrWjvNHCkk4w4NI1ojNSOE1063THSau1NFtMt-WayU4QA9pRJ51uuCCtALpGFwfe23k72s6UrpIe1G3yo053Kmqv_n8J_ofaxb1iIFuQC8G7I0GKv2abJzX6bOww6GDjnBWWlDXAmWyfACWixULCAn37ANrHOYWyiQUlCZdQ5l8jdkCZFHNO1t33jUEtEqpeHSVUi4QKSsBS9-bfoe-r_mhWAO8PAFtWv_c2qVxECcZ2PlkzqS76R7-4eMBgBh8WF_y0dzb_nUZlokDdLD5abIQ5BdowQn8DsG_FAQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Zeltsman, Masha, DO</creator><creator>Mayor, Marissa, MD</creator><creator>Jones, David R., MD, FACS</creator><creator>Adusumilli, Prasad S., MD, FACS, FCCP</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1699-2046</orcidid></search><sort><creationdate>20161001</creationdate><title>Surgical immune interventions for solid malignancies</title><author>Zeltsman, Masha, DO ; Mayor, Marissa, MD ; Jones, David R., MD, FACS ; Adusumilli, Prasad S., MD, FACS, FCCP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-f364a7e2d75068f47dc87fa2a9fad629aa8cb13bdc858d72c0af3f8fa46729703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenoviruses</topic><topic>Adoptive cell therapy</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antigens</topic><topic>BCG Vaccine</topic><topic>Catheterization</topic><topic>Clinical trials</topic><topic>Clinical Trials as Topic</topic><topic>Colorectal cancer</topic><topic>Combined Modality Therapy</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Dendritic cells</topic><topic>Gangrene</topic><topic>Gastric cancer</topic><topic>Granulocytes</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Injections, Intralesional</topic><topic>Iodine</topic><topic>Laparoscopy</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Lymphocytes</topic><topic>Melanoma</topic><topic>Mesothelioma</topic><topic>Metastasis</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Ovarian cancer</topic><topic>Patients</topic><topic>Pharmaceutical industry</topic><topic>Regional immunotherapy</topic><topic>Studies</topic><topic>Surgery</topic><topic>Surgical immunotherapy</topic><topic>Tumor Microenvironment</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><topic>Vaccines</topic><topic>Vascular Access Devices</topic><topic>Vectors (Biology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeltsman, Masha, DO</creatorcontrib><creatorcontrib>Mayor, Marissa, MD</creatorcontrib><creatorcontrib>Jones, David R., MD, FACS</creatorcontrib><creatorcontrib>Adusumilli, Prasad S., MD, FACS, FCCP</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeltsman, Masha, DO</au><au>Mayor, Marissa, MD</au><au>Jones, David R., MD, FACS</au><au>Adusumilli, Prasad S., MD, FACS, FCCP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical immune interventions for solid malignancies</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>212</volume><issue>4</issue><spage>682</spage><epage>690.e5</epage><pages>682-690.e5</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Structured Abstract Background The purpose of this study was to systematically review clinically translatable immunotherapeutic agents that are delivered regionally for solid malignancies. Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respectively. The search yielded 334 relevant publications, of which 116 manuscripts were included for review after exclusion criteria were applied. Conclusions There has been an increase in the regional administration of cell-based and viral vector-based clinical trials over the last 5 years. Surgical interventions have been developed for intrapleural, intracranial, intraperitoneal, and intratumoral routs of access to enhance the local delivery of there therapies. Multimodality therapies that combine regional immunotherapy with other local and systemic therapies are demonstrating continued growth as the field of immunotherapy continues to expand.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27659157</pmid><doi>10.1016/j.amjsurg.2016.06.008</doi><orcidid>https://orcid.org/0000-0002-1699-2046</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoviruses Adoptive cell therapy Antibodies, Monoclonal - therapeutic use Antigens BCG Vaccine Catheterization Clinical trials Clinical Trials as Topic Colorectal cancer Combined Modality Therapy Cytokines Cytotoxicity Dendritic cells Gangrene Gastric cancer Granulocytes Humans Immune system Immunotherapy Immunotherapy - methods Injections, Intralesional Iodine Laparoscopy Liver cancer Lung cancer Lymphocytes Melanoma Mesothelioma Metastasis Neoplasms - pathology Neoplasms - therapy Ovarian cancer Patients Pharmaceutical industry Regional immunotherapy Studies Surgery Surgical immunotherapy Tumor Microenvironment Tumor necrosis factor-TNF Tumors Vaccines Vascular Access Devices Vectors (Biology) |
| title | Surgical immune interventions for solid malignancies |
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