The association between race and treatment regret among men with recurrent prostate cancer

• Published in: Prostate cancer and prostatic diseases 2015-03, Vol.18 (1), p.38-42
• Main Authors: Mahal, B A, Chen, M-H, Bennett, C L, Kattan, M W, Sartor, O, Stein, K, D'Amico, A V, Nguyen, P L
• Format: Article
• Language: English
• Subjects: 692/308/575; Adenocarcinoma; African Continental Ancestry Group; Aged; Aged, 80 and over; Analysis; Biomedical and Life Sciences; Biomedicine; Brachytherapy; Brachytherapy - psychology; Cancer recurrence; Cancer Research; Cancer surgery; Cancer treatment; Care and treatment; Confidence intervals; Demographic aspects; Emotions; Humans; Male; Methods; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - psychology; original-article; Physicians; Prospective Studies; Prostate cancer; Prostatectomy; Prostatectomy - psychology; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - pathology; Prostatic Neoplasms - psychology; Race; Radiation; Radiation therapy; Regression analysis; Regression models; Statistical analysis; Surgery; Treatment Outcome; Urological surgery
• ISSN: 1365-7852; 1476-5608
• DOI: 10.1038/pcan.2014.42

Background: To examine the impact of race on treatment regret among men with recurrent prostate cancer after surgery or radiation. Methods: The prospective Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma (COMPARE) registry was used to study a cohort of 484 men with biochemically recurrent prostate cancer after radical prostatectomy, external beam radiation or brachytherapy. Multivariable logistic regression was used to model the association between race and treatment regret and to determine whether there was an interaction between race and sexual problems after treatment with regards to treatment regret. Results: Black men ( N =78) were significantly more likely to have treatment regret when compared with non-black men ( N =406; 21.8% versus 12.6%) on univariable analysis (odds ratio (OR) 1.94; 95% confidence interval 1.05–3.56; P =0.03). On multivariable analysis, black race trended towards but was no longer significantly associated with an increase in treatment regret (adjusted OR (AOR) 1.84 (0.95–3.58); P =0.071). There was an interaction between race and sexual problems after treatment ( P interaction =0.02) such that among those without sexual problems, black men had more treatment regret than non-black men (26.7% versus 8.4%: AOR 4.68 (1.73–12.63); P =0.002), whereas among those with sexual problems, there was no difference in treatment regret between black and non-black men (18.8% versus 17.3%: AOR 1.04 (0.44–2.46); P =0.93). Conclusions: Among men with recurrent prostate cancer after surgery or radiation, black men were nearly twice as likely to experience treatment regret. Treating physicians should ensure that patients are fully apprised of the pros and cons of all treatment options to reduce the risk of subsequent regret.