Decreased bone mineral density in Prader-Willi syndrome: Comparison with obese subjects

Bone density, anthropometric data, and markers of bone turnover were collected on 21 subjects diagnosed with Prader‐Willi syndrome (PWS) and compared with 9 subjects with obesity of unknown cause. In addition, urinary N‐telopeptide levels were obtained in all subjects. N‐telopeptides are the peptide...

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Bibliographic Details
Published in:American journal of medical genetics 2001-10, Vol.103 (3), p.216-222
Main Authors: Butler, Merlin G., Haber, Lawrence, Mernaugh, Ray, Carlson, Michael G., Price, Ron, Feurer, Irene D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Biological and medical sciences
Bone Density
bone mineral content
bone mineral density
Child
Chromosomes, Human, Pair 15 - genetics
Collagen - urine
Collagen Type I
DEXA
Estrogens - blood
Female
Humans
Male
Medical sciences
Metabolic diseases
Middle Aged
N-telopeptides
Obesity
Obesity - pathology
Obesity - urine
Peptides - urine
Prader-Willi syndrome
Prader-Willi Syndrome - diagnosis
Prader-Willi Syndrome - genetics
Prader-Willi Syndrome - pathology
Prader-Willi Syndrome - urine
Sex Factors
Statistics as Topic
Testosterone - blood
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Summary:Bone density, anthropometric data, and markers of bone turnover were collected on 21 subjects diagnosed with Prader‐Willi syndrome (PWS) and compared with 9 subjects with obesity of unknown cause. In addition, urinary N‐telopeptide levels were obtained in all subjects. N‐telopeptides are the peptide fragments of type I collagen, the major bone matrix material. During periods of active bone degradation or high bone turnover, high levels of N‐telopeptides are excreted in the urine. However, no significant difference was detected in the urinary N‐telopeptide levels when corrected for creatinine excretion (raw or transformed data) between our subjects with obesity or PWS and the observed effect size of the between‐group difference was small. Although N‐telopeptide levels were higher but not significantly different in the subjects with PWS compared with obese controls, the subjects with PWS had significantly decreased total bone and spine mineral density and total bone mineral content (all P 
ISSN:0148-7299
1096-8628
DOI:10.1002/ajmg.1556