Pre-ART nutritional status and its association with mortality in adult patients enrolled on ART at Fiche Hospital in North Shoa, Oromia region, Ethiopia: a retrospective cohort study

Human immunodeficiency virus (HIV) compromises the nutritional status of infected individuals and in turn, malnutrition worsens the effects of the infection itself by weakening the immune system consequently accelerating disease progression and death. However, few studies have examined the associati...

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Bibliographic Details
Published in:BMC research notes 2016-12, Vol.9 (1), p.512-512, Article 512
Main Authors: Tesfamariam, Kokeb, Baraki, Negga, Kedir, Haji
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis
Anti-HIV Agents - therapeutic use
Antiviral agents
CD4 Lymphocyte Count
Data Collection
Disease Progression
Ethiopia
Female
Food and nutrition
Health aspects
HIV Infections - drug therapy
HIV Infections - mortality
HIV Infections - physiopathology
HIV patients
Humans
Kaplan-Meier Estimate
Male
Malnutrition
Mortality
Nutritional Status
Proportional Hazards Models
Retrospective Studies
Risk Factors
Sample Size
Young Adult
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Summary:Human immunodeficiency virus (HIV) compromises the nutritional status of infected individuals and in turn, malnutrition worsens the effects of the infection itself by weakening the immune system consequently accelerating disease progression and death. However, few studies have examined the association between nutritional status at antiretroviral therapy (ART) initiation and early mortality. Therefore, this study assesses pre-ART nutritional status and other baseline characteristics and mortality among adult patients on ART at Fiche Hospital, Ethiopia. A retrospective cohort study was conducted among 489 ART enrolled adult patients between August 01, 2006 and September 30, 2013 in Fiche Hospital. Study participants were selected by using systematic random sampling method. Actuarial table was used to estimate survival of patients after ART initiation and log rank test was used to compare the survival curves. Cox proportional-hazard regression was used to determine independent predictors of time to death. Most of the study subjects were females 254 (51.9%). A total of 489 patients were included in the analysis, of whom 87 died during a median study follow-up of 22 months. The estimated mortality among malnourished was 21, 28, 33, and 38% at 5, 10, 15, and 25 months respectively with mortality incidence density of 5.63 deaths per 100 person years. The independent predictors of mortality were: BMI
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-016-2313-y