Organ Chips: Quality Assurance Systems in Regenerative Medicine

A class of novel therapies leverages regenerative cell types in disease microenvironments. This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. That is, we can build the product right, but we do not...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2017-01, Vol.101 (1), p.31-34
Main Authors: Pasqualini, FS, Emmert, MY, Parker, KK, Hoerstrup, SP
Format: Article
Language:English
Subjects:
Biomimetic Materials
Cell- and Tissue-Based Therapy - methods
Cellular Microenvironment
Humans
Phenotype
Quality Assurance, Health Care
Regenerative Medicine - methods
Regenerative Medicine - standards
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Summary:A class of novel therapies leverages regenerative cell types in disease microenvironments. This complex interplay challenges established good manufacturing practices, as standards and analytical tools to measure regenerative potency are missing. That is, we can build the product right, but we do not know if we are building the right product. Here, we suggest that organ‐chips, biomimetic in vitro phenotyping platforms, can serve as key quality assurance systems in regenerative medicine.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.527