Thalamic Atrophy Contributes to Low Slow Wave Sleep in Neuromyelitis Optica Spectrum Disorder

Slow wave sleep abnormality has been reported in neuromyelitis optica spectrum disorder (NMOSD), but mechanism for such abnormality is unknown. To determine the structural defects in the brain that account for the decrease of slow wave sleep in NMOSD patients. Thirty-three NMOSD patients and 18 matc...

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Bibliographic Details
Published in:Aging and disease 2016-12, Vol.7 (6), p.691-696
Main Authors: Su, Lei, Han, Yujuan, Xue, Rong, Wood, Kristofer, Shi, Fu-Dong, Liu, Yaou, Fu, Ying
Format: Article
Language:English
Subjects:
Atrophy
Complications and side effects
Development and progression
Diagnostic imaging
Health aspects
Hormones
Medical research
Neuromyelitis optica
Patient monitoring equipment
Risk factors
Short Communications
Sleep
Sleep disorders
Slow-wave sleep
Thalamus
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Summary:Slow wave sleep abnormality has been reported in neuromyelitis optica spectrum disorder (NMOSD), but mechanism for such abnormality is unknown. To determine the structural defects in the brain that account for the decrease of slow wave sleep in NMOSD patients. Thirty-three NMOSD patients and 18 matched healthy controls (HC) were enrolled. Polysomnography was used to monitor slow wave sleep and three-dimensional T1-weighted MRIs were obtained to assess the alterations of grey matter volume. The percentage of deep slow wave sleep decreased in 93% NMOSD patients. Compared to HC, a reduction of grey matter volume was found in the bilateral thalamus of patients with a lower percentage of slow wave sleep (FWE corrected at cluster-level, p < 0.05, cluster size > 400 voxels). Furthermore, the right thalamic fraction was positively correlated with the decrease in the percentage of slow wave sleep in NMOSD patients (p < 0.05, FDR corrected, cluster size > 200 voxels). Our study identified that thalamic atrophy is associated with the decrease of slow wave sleep in NMOSD patients. Further studies should evaluate whether neurotransmitters or hormones which stem from thalamus are involved in the decrease of slow wave sleep.
ISSN:2152-5250
2152-5250
DOI:10.14336/ad.2016.0419