The contribution of neutrophils to CNS autoimmunity

Abstract Multiple sclerosis (MS) is believed to be initiated when myelin-specific T cells infiltrate the central nervous system (CNS), triggering subsequent recruitment of inflammatory leukocytes to the CNS. The contribution of neutrophils to CNS autoimmune disease has been underappreciated, but sev...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2018-04, Vol.189, p.23-28
Main Authors: Pierson, Emily R, Wagner, Catriona A, Goverman, Joan M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Autoimmunity - immunology
Central Nervous System - immunology
Central Nervous System - metabolism
CXCR2
Cytokines - immunology
Cytokines - metabolism
EAE
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - metabolism
Humans
IL-17
Multiple Sclerosis - immunology
Multiple Sclerosis - metabolism
Neutrophil Infiltration - immunology
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
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Summary:Abstract Multiple sclerosis (MS) is believed to be initiated when myelin-specific T cells infiltrate the central nervous system (CNS), triggering subsequent recruitment of inflammatory leukocytes to the CNS. The contribution of neutrophils to CNS autoimmune disease has been underappreciated, but several studies in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, indicate that neutrophils have an important role in inflammation. Neutrophils are hypothesized to contribute to the pathogenesis of EAE by producing cytokines and promoting breakdown of the blood brain barrier. Neutrophils may also influence the manifestation of EAE by facilitating parenchymal brain inflammation. This review summarizes evidence supporting a functional role for neutrophils in EAE and MS, highlighting the differential regulation of neutrophil recruitment in the brain and spinal cord.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2016.06.017