Loading…

Computed tomograpy evaluation of morphological changes, clinical response and survival in colorectal cancer liver metastasis treated by regorafenib: A case report

Pathological response to preoperative chemotherapy was recently found to be correlated with improved survival and has been proposed as a new outcome end-point following resection of liver metastases from colorectal cancer (CRC). It was demonstrated that, particularly after therapy with bevacizumab,...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and clinical oncology 2016-12, Vol.5 (6), p.807-810
Main Authors: Matsuhashi, Nobuhisa, Takahashi, Takao, Kato, Junko, Tanahashi, Toshiyuki, Matsui, Satoshi, Sasaki, Yoshiyuki, Imai, Hisashi, Tanaka, Yoshihiro, Okumura, Naoki, Yamaguchi, Kazuya, Futamura, Manabu, Osada, Shinji, Yoshida, Kazuhiro
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pathological response to preoperative chemotherapy was recently found to be correlated with improved survival and has been proposed as a new outcome end-point following resection of liver metastases from colorectal cancer (CRC). It was demonstrated that, particularly after therapy with bevacizumab, CRC liver metastases decreased in size and underwent distinct morphological changes on computed tomography (CT). However, morphological changes in response to treatment with regorafenib have not yet been reported. A 73-year-old male patient with synchronous multiple liver and lung metastases from colon cancer was treated with regorafenib as a fifth-line therapy. CT imaging revealed a decrease in the tumor size and distinct morphological changes, namely homogeneous attenuation and sharp tumor-liver interface. The patient continued to take regorafenib for 8 months. Thus, regorafenib appeared to be effective as a last-line chemotherapy. In particular, the unique morphological changes of the metastases on CT imaging of may represent a method for evaluating the effects of CRC cancer therapy.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2016.1045