Inactivation of the Anterior Cingulate Cortex Impairs Extinction of Rabbit Jaw Movement Conditioning and Prevents Extinction-Related Inhibition of Hippocampal Activity

Although past research has highlighted the involvement of limbic structures such as the anterior cingulate cortex (ACC) and hippocampus in learning, few have addressed the nature of their interaction. The current study of rabbit jaw movement conditioning used a combination of reversible lesions and...

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Bibliographic Details
Published in:Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2004-09, Vol.11 (5), p.604-610
Main Authors: Griffin, Amy L, Berry, Stephen D
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Association Learning - physiology
Biomechanics
Brain
Brain Hemisphere Functions
Circadian Rhythm
Conditioning
Conditioning, Classical - physiology
Evoked Potentials, Motor - physiology
Extinction, Psychological - physiology
Gyrus Cinguli - physiology
Hippocampus - physiology
Inhibition
Interaction
Jaw
Mastication - physiology
Movement - physiology
Neural Inhibition - physiology
Neural Pathways - physiology
Physiology
Rabbits
Research Papers
Stimuli
Task Analysis
Training
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Summary:Although past research has highlighted the involvement of limbic structures such as the anterior cingulate cortex (ACC) and hippocampus in learning, few have addressed the nature of their interaction. The current study of rabbit jaw movement conditioning used a combination of reversible lesions and electrophysiology to examine the involvement of the hippocampus and the ACC during acquisition, performance, and extinction. We found that microinfusions of procaine into the ACC did not significantly alter the rate of behavioral learning or the amplitude of hippocampal conditioned unit responses, but that they disrupted the rhythmic periodicity of conditioned jaw movements. During extinction, whereas controls showed a rapid decline in behavioral CRs and active inhibition of hippocampal unit responses, ACC lesioned rabbits showed a persistence of conditioning-related hippocampal activity and behavioral responding. The results show that the ACC can be important for adaptive suppression of conditioned behavior and suggest a crucial physiological modulation of hippocampus by ACC during extinction. (Contains 5 figures.)
ISSN:1072-0502
1549-5485
DOI:10.1101/lm.78404