From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short-chain fatty acids (SCFAs), which are subseque...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2014-12, Vol.307 (11), p.C979-C985
Main Authors: Natarajan, Niranjana, Pluznick, Jennifer L
Format: Article
Language:English
Subjects:
Bacteria - metabolism
Cellular biology
Fatty acids
Fatty Acids, Volatile - chemistry
Fatty Acids, Volatile - metabolism
Gastrointestinal Tract - microbiology
Humans
Metabolites
Microorganisms
Review
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Summary:Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short-chain fatty acids (SCFAs), which are subsequently absorbed into the bloodstream of the host. Although recent studies have begun to unravel the ways in which gut microbial SCFAs affect host physiology, less is understood regarding the underlying cell biological mechanisms. In this review, we will outline the known receptors and transporters for SCFAs, and review what is known about the cell biological effects of microbial SCFAs.
ISSN:0363-6143
1522-1563
DOI:10.1152/ajpcell.00228.2014