Filarial Abundant Larval Transcript Protein ALT-2: An Immunomodulatory Therapeutic Agent for Type 1 Diabetes

Type 1 diabetes (T1D) that accounts for about 5–10 % of all diabetes cases results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. It is characterized by severe inflammatory reaction mediated by pronounced T helper type-1 response. Parasitic infections having the...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of clinical biochemistry 2017-03, Vol.32 (1), p.45-52
Main Authors: Reddy, Sridhar M., Reddy, Pooja M., Amdare, Nitin, Khatri, Vishal, Tarnekar, Aaditya, Goswami, Kalyan, Reddy, Maryada Venkata Rami
Format: Article
Language:English
Subjects:
Autoimmune diseases
Autoimmunity
Biochemistry
Biomedical and Life Sciences
Blood sugar
Brugia malayi
Chemistry/Food Science
Development and progression
Diabetes
Drug therapy
Health aspects
Immune response
Immune system
Immunoglobulin G
Inflammation
Life Sciences
Microbiology
Original
Original Article
Parasites
Parasitic diseases
Pathology
Proteins
Type 1 diabetes
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Type 1 diabetes (T1D) that accounts for about 5–10 % of all diabetes cases results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. It is characterized by severe inflammatory reaction mediated by pronounced T helper type-1 response. Parasitic infections having the ability to skew the host immune responses towards type-2 type as a part of their defense mechanism are able to induce protection against autoimmune diseases like T1D. Hence, the present study is undertaken to explore a recombinant abundant larval transcript protein of the human lymphatic filarial parasite Brugia malayi ( rBm ALT-2), a known anti-inflammatory molecule for its therapeutic effect on streptozotocin (STZ)-induced T1D in mice. The diabetic mice on treatment with r Bm ALT-2 showed a significant ( p  
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-016-0572-y