Topical Treatment for Onychomycosis: Is it More Effective than the Clinical Data Suggests?

Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consiste...

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Bibliographic Details
Published in:The Journal of clinical and aesthetic dermatology 2016-11, Vol.9 (11), p.34-39
Main Authors: Elewski, Boni E, Vlahovic, Tracey C., Korotzer, Andrew
Format: Article
Language:English
Subjects:
Review
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Summary:Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consistently report secondary endpoints, making data comparison difficult. Methods: The authors review the clinical data reported on two new topical antifungals, efinaconazole and tavaborole, in light of the latest thinking of more practical approaches to assess improvement and treatment success. Results: Almost 20 percent (19.7%) of patients treated with efinaconazole had absence of clinical signs, and almost a third (31.6%) had ≤10 percent affected toenail and mycologic cure at Week 52. Cure rates for tavaborole (
ISSN:1941-2789