Third generation drug eluting stent (DES) with biodegradable polymer in diabetic patients: 5 years follow-up

To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in the complex patient population of diabetes mellitus after a follow-up period of 5 years. After percutaneous coronary intervention patients with diabetes mellitus are under hi...

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Bibliographic Details
Published in:Cardiovascular diabetology 2017-02, Vol.16 (1), p.23-23, Article 23
Main Authors: Wiemer, Marcus, Stoikovic, Sinisa, Samol, Alexander, Dimitriadis, Zisis, Ruiz-Nodar, Juan M, Birkemeyer, Ralf, Monsegu, Jacques, Finet, Gérard, Hildick-Smith, David, Tresukosol, Damras, Novo, Enrique Garcia, Koolen, Jacques J, Barbato, Emanuele, Danzi, Gian Battista
Format: Article
Language:English
Subjects:
Absorbable Implants
Aged
Coronary Artery Disease - diagnosis
Coronary Artery Disease - mortality
Coronary Artery Disease - therapy
Coronary Restenosis - etiology
Coronary Thrombosis - etiology
Diabetes Mellitus - diagnosis
Diabetes Mellitus - drug therapy
Diabetes Mellitus - mortality
Drug-Eluting Stents
Female
Humans
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Insulin - adverse effects
Insulin - therapeutic use
Kaplan-Meier Estimate
Male
Middle Aged
Original Investigation
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - instrumentation
Percutaneous Coronary Intervention - mortality
Platelet Aggregation Inhibitors - therapeutic use
Polymers - chemistry
Prospective Studies
Prosthesis Design
Registries
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
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Summary:To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in the complex patient population of diabetes mellitus after a follow-up period of 5 years. After percutaneous coronary intervention patients with diabetes mellitus are under higher risk of death, restenosis and stent thrombosis (ST) compared to non-diabetic patients. In 126 centers worldwide 3067 patients were enrolled in the NOBORI 2 registry, 888 patients suffered from diabetes mellitus (DM), 213 of them (14%) being insulin dependent (IDDM). Five years follow-up has been completed in this study. At 5 years, 89.3% of the patients were available for follow-up. The reported target lesion failure (TLF) rates at 5 years were 12.39% in DM group and 7.34% in non-DM group; (p 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-017-0500-3