Iron Reduces M1 Macrophage Polarization in RAW264.7 Macrophages Associated with Inhibition of STAT1

Iron metabolism in inflammation has been mostly characterized in macrophages exposed to pathogens or inflammatory conditions. The aim of this study is to investigate the cross-regulatory interactions between M1 macrophage polarization and iron metabolism. Firstly, we characterized the transcription...

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Bibliographic Details
Published in:Mediators of inflammation 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Wang, Yi-Zhen, Wang, Xu-Liang, Li, Jia-Hui, Wang, Qian-Qian, Gan, Zhen-Shun, Du, Hua-Hua
Format: Article
Language:English
Subjects:
Animal sciences
Animals
Antigens
Cation Transport Proteins - metabolism
Cell growth
Colleges & universities
Cytokines
Cytotoxicity
Ferritins - metabolism
Gene expression
Health aspects
Homeostasis
Infections
Interferon-gamma - pharmacology
Interleukin-1beta - genetics
Interleukin-6 - genetics
Iron (Nutrient)
Iron - pharmacology
Iron in the body
Laboratories
Macrophages
Macrophages - drug effects
Macrophages - metabolism
Mice
Nitric Oxide Synthase Type II - genetics
Proteins
RAW 264.7 Cells
Receptors, Transferrin - metabolism
Retention
RNA, Messenger - genetics
Rodents
STAT1 Transcription Factor - metabolism
Tumor Necrosis Factor-alpha - genetics
Zoology
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