Low acylation stimulating protein levels are associated with cardiometabolic disorders-secondary to autoimmune activation?

We investigated the possible association of serum acylation stimulating protein (ASP) with cardiometabolic disorders and the evidence of autoimmune activation. Population-based randomly selected 1024 participants were cross-sectionally and prospectively analyzed. ASP concentrations were measured wit...

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Bibliographic Details
Published in:Anatolian journal of cardiology 2017-02, Vol.17 (2), p.97-106
Main Authors: Onat, Altan, Altay, Servet, Yüksel, Murat, Karadeniz, Yusuf, Can, Günay, Yüksel, Hüsniye, Ademoğlu, Evin
Format: Article
Language:English
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Original Investigation
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Summary:We investigated the possible association of serum acylation stimulating protein (ASP) with cardiometabolic disorders and the evidence of autoimmune activation. Population-based randomly selected 1024 participants were cross-sectionally and prospectively analyzed. ASP concentrations were measured with a validated ELISA kit. Correlations were sought separately in subjects with no cardiometabolic disorders (n=427) designated as "healthy." ASP was positively correlated with total testosterone and inversely correlated with platelet activating factor (PAF), PAF-acetylhydrolase (AH), in each gender, and positively correlated in "healthy" men with lipoprotein [Lp](a) and apolipoprotein B. Correlations of ASP with PAF values ≥22 nmol/L were abolished, contrasted to a strongly inverse one in subjects with PAF
ISSN:2149-2263
2149-2271
DOI:10.14744/AnatolJCardiol.2016.7024