Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats

Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain. An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-14
Main Authors: Chen, Chao-Hsiang, Cheng, Chin-Yi, Ho, Tin-Yun, Lin, Yi-Wen, Tang, Nou-Ying, Hsieh, Ching-Liang
Format: Article
Language:English
Subjects:
Brain
Brain damage
Brain research
Cell growth
Chemokines
Chronic illnesses
Colleges & universities
Convulsions & seizures
Divalproex
Electroencephalography
Epilepsy
Glutamate
Inflammation
Kinases
Medicine
Neurons
Proteins
Research centers
Rodents
Seizures (Medicine)
Traumatic brain injury
Valproic acid
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Summary:Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain. An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects. We established a rat epilepsy model by injecting kainic acid (KA, 12 mg/kg, i.p.) and subsequently investigated the effect of Uncaria rhynchophylla (UR) and its underlying mechanisms. Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures. Following KA injection, S100B levels increased in the hippocampus. This phenomenon was attenuated by the oral administration of UR and valproic acid (VA, 250 mg/kg). Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins. Rats with KA-induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation. Our results provide novel and detailed mechanisms, explaining the role of UR in KA-induced epileptic seizures in hippocampal CA1 neurons.
ISSN:1741-427X
1741-4288
DOI:10.1155/2017/9732854