Cardiac Autonomic Alteration and Metabolic Syndrome: An Ambulatory ECG-based Study in A General Population

Metabolic syndrome (MetS) has been associated with chronic damage to the cardiovascular system. This study aimed to evaluate early stage cardiac autonomic dysfunction with electrocardiography (ECG)-based measures in MetS subjects. During 2012–2013, 175 subjects with MetS and 226 healthy controls und...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.44363-44363, Article 44363
Main Authors: Ma, Yan, Tseng, Ping-Huei, Ahn, Andrew, Wu, Ming-Shiang, Ho, Yi-Lwun, Chen, Ming-Fong, Peng, Chung-Kang
Format: Article
Language:English
Subjects:
631/57
692/163/2743/2037
Adult
Autonomic Nervous System - diagnostic imaging
Autonomic Nervous System - physiopathology
Cardiovascular system
Cardiovascular System - diagnostic imaging
Cardiovascular System - physiopathology
Case-Control Studies
EKG
Electrocardiography
Electrocardiography, Ambulatory
Entropy
Female
Heart - diagnostic imaging
Heart - physiopathology
Heart diseases
Heart Rate
Humanities and Social Sciences
Humans
Male
Metabolic syndrome
Metabolic Syndrome - diagnostic imaging
Metabolic Syndrome - physiopathology
Middle Aged
multidisciplinary
Population studies
Retrospective Studies
Science
Waist Circumference
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolic syndrome (MetS) has been associated with chronic damage to the cardiovascular system. This study aimed to evaluate early stage cardiac autonomic dysfunction with electrocardiography (ECG)-based measures in MetS subjects. During 2012–2013, 175 subjects with MetS and 226 healthy controls underwent ECG recordings of at least 4 hours starting in the morning with ambulatory one-lead ECG monitors. MetS was diagnosed using the criteria defined in the Adult Treatment Panel III, with a modification of waist circumference for Asians. Conventional heart rate variability (HRV) analysis, and complexity index (CI 1–20 ) calculated from 20 scales of entropy (multiscale entropy, MSE), were compared between subjects with MetS and controls. Compared with the healthy controls, subjects with MetS had significantly reduced HRV, including SDNN and pNN20 in time domain, VLF, LF and HF in frequency domain, as well as SD2 in Poincaré analysis. MetS subjects have significantly lower complexity index (CI 1–20 ) than healthy subjects (1.69 ± 0.18 vs. 1.77 ± 0.12, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep44363