Human rotavirus strains circulating in Venezuela after vaccine introduction: predominance of G2P[4] and reemergence of G1P[8]

Rotavirus (RV) is the most common cause of severe childhood diarrhea worldwide. Despite Venezuela was among the first developing countries to introduce RV vaccines into their national immunization schedules, RV is still contributing to the burden of diarrhea. Concerns exist about the selective press...

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Bibliographic Details
Published in:Virology journal 2017-03, Vol.14 (1), p.58-58, Article 58
Main Authors: Vizzi, Esmeralda, Piñeros, Oscar A, Oropeza, M Daniela, Naranjo, Laura, Suárez, José A, Fernández, Rixio, Zambrano, José L, Celis, Argelia, Liprandi, Ferdinando
Format: Article
Language:English
Subjects:
Developing countries
Diarrhea
Female
Genes
Genomes
Genotype
Genotype & phenotype
Genotyping Techniques
Health surveillance
Humans
Infant
Infections
LDCs
Male
Molecular Epidemiology
Multiplex Polymerase Chain Reaction
Prevalence
Public health
Reverse Transcriptase Polymerase Chain Reaction
Rotavirus
Rotavirus - classification
Rotavirus - genetics
Rotavirus - isolation & purification
Rotavirus Infections - epidemiology
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - immunology
Vaccines
Venezuela - epidemiology
Viruses
Working groups
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Summary:Rotavirus (RV) is the most common cause of severe childhood diarrhea worldwide. Despite Venezuela was among the first developing countries to introduce RV vaccines into their national immunization schedules, RV is still contributing to the burden of diarrhea. Concerns exist about the selective pressure that RV vaccines could exert on the predominant types and/or emergence of new strains. To assess the impact of RV vaccines on the genotype distribution 1 year after the vaccination was implemented, a total of 912 fecal specimens, collected from children with acute gastroenteritis in Caracas from February 2007 to April 2008, were screened, of which 169 (18.5%) were confirmed to be RV positive by PAGE. Rotavirus-associated diarrhea occurred all year-round, although prevailed during the coolest and driest months among unvaccinated children under 24 months old. Of 165 RV strains genotyped for G (VP7) and P (VP4) by seminested multiplex RT-PCR, 77 (46.7%) were G2P[4] and 63 (38.2%) G1P[8]. G9P[8], G3P[8] and G2P[6] were found in a lower proportion (7.3%). Remarkable was also the detection of
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-017-0721-9