Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families

Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-03, Vol.195 (5), p.674-681
Main Authors: Ramratnam, Sima K, Visness, Cynthia M, Jaffee, Katy F, Bloomberg, Gordon R, Kattan, Meyer, Sandel, Megan T, Wood, Robert A, Gern, James E, Wright, Rosalind J
Format: Article
Language:English
Subjects:
Asthma - epidemiology
Asthma - immunology
Asthma - psychology
Child, Preschool
Cytokines - immunology
Depressive Disorder - epidemiology
Depressive Disorder - immunology
Depressive Disorder - psychology
Female
Humans
Leukocytes, Mononuclear - immunology
Male
Mothers - psychology
Original
Poverty - psychology
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - immunology
Pregnancy Complications - psychology
Recurrence
Respiratory Sounds - immunology
Risk Factors
Stress, Psychological - epidemiology
Stress, Psychological - immunology
Stress, Psychological - psychology
Urban Population - statistics & numerical data
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Summary:Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years. URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years. Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P 
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201602-0272OC