Genome-wide association study of working memory brain activation

In a population-based genome-wide association (GWA) study of n-back working memory task-related brain activation, we extracted the average percent BOLD signal change (2-back minus 0-back) from 46 regions-of-interest (ROIs) in functional MRI scans from 863 healthy twins and siblings. ROIs were obtain...

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Bibliographic Details
Published in:International journal of psychophysiology 2017-05, Vol.115, p.98-111
Main Authors: Blokland, Gabriëlla A.M., Wallace, Angus K., Hansell, Narelle K., Thompson, Paul M., Hickie, Ian B., Montgomery, Grant W., Martin, Nicholas G., McMahon, Katie L., de Zubicaray, Greig I., Wright, Margaret J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
BOLD signal
Brain - diagnostic imaging
Brain - physiology
Community Health Planning
Female
Functional MRI
Genome-Wide Association Study
Genotype
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Memory, Short-Term - physiology
Models, Genetic
n-back
Neuropsychological Tests
Oxygen - blood
Phenotype
Polymorphism, Single Nucleotide - genetics
Region-of-interest
Reproducibility of Results
Twins
Working memory
Young Adult
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Summary:In a population-based genome-wide association (GWA) study of n-back working memory task-related brain activation, we extracted the average percent BOLD signal change (2-back minus 0-back) from 46 regions-of-interest (ROIs) in functional MRI scans from 863 healthy twins and siblings. ROIs were obtained by creating spheres around group random effects analysis local maxima, and by thresholding a voxel-based heritability map of working memory brain activation at 50%. Quality control for test-retest reliability and heritability of ROI measures yielded 20 reliable (r>0.7) and heritable (h2>20%) ROIs. For GWA analysis, the cohort was divided into a discovery (n=679) and replication (n=97) sample. No variants survived the stringent multiple-testing-corrected genome-wide significance threshold (p
ISSN:0167-8760
1872-7697
DOI:10.1016/j.ijpsycho.2016.09.010