Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice

Hyperuricemia is recognized as an important risk factor for gout. High dietary intake of purine-rich foods such as meats and sea foods increases uric acid (UA) levels in the blood. Taxifolin present in Siberian larch and strawberries has been reported to possess health promoting activities including...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2017-04, Vol.69 (2), p.329-336
Main Authors: Adachi, Shin-ichi, Nihei, Ken-ichi, Ishihara, Yoshiyuki, Yoshizawa, Fumiaki, Yagasaki, Kazumi
Format: Article
Language:English
Subjects:
Animal models
Biochemistry
Biomedicine
Biotechnology
Chemistry
Chemistry and Materials Science
Dietary intake
Flavonoids
Food
Food intake
Gout
Guanosine
Hepatocytes
Hyperuricemia
Liver
Oral administration
Original
Original Article
Oxidants
Penicillin
Plasma
Potassium
Proteins
Rheumatism
Risk factors
Rodents
Selenium
Uric acid
Xanthine oxidase
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Summary:Hyperuricemia is recognized as an important risk factor for gout. High dietary intake of purine-rich foods such as meats and sea foods increases uric acid (UA) levels in the blood. Taxifolin present in Siberian larch and strawberries has been reported to possess health promoting activities including anti-oxidant effect. In this study, we examined anti-hyperuricemic effect of taxifolin in both cultured hepatocytes and hyperuricemic model mice. In cultured AML12 hepatocytes, taxifolin significantly suppressed UA production dose- and time-dependently. In mice with hyperuricemia induced by concurrent administration of guanosine-5′-monophosphate and inosine-5′-monophosphate, oral administration of taxifolin suppressed the increases in plasma and liver UA levels. In addition, it also suppressed hepatic xanthine oxidase (XO) activity. Thus, anti-hyperuricemic effect of taxifolin could be explained, at least partly, by suppressing UA production via inhibition of XO activity in the liver. These results suggest that taxifolin possesses a potent hypouricemic effect and it could be a potential candidate for an anti-hyperuricemic phytochemical.
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-016-0061-4