MET4 expression predicts poor prognosis of gastric cancers with Helicobacter pylori infection

The role of HGF/SF‐MET signaling is important in cancer progression, but its relation with Helicobacter pylori‐positive gastric cancers remains to be elucidated. In total, 201 patients with primary gastric carcinoma who underwent curative or debulking resection without preoperative chemotherapy were...

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Bibliographic Details
Published in:Cancer science 2017-03, Vol.108 (3), p.322-330
Main Authors: Sakamoto, Naoko, Tsujimoto, Hironori, Takahata, Risa, Cao, Brian, Zhao, Ping, Ito, Nozomi, Shimazaki, Hideyuki, Ichikura, Takashi, Hase, Kazuo, Vande Woude, George F., Shinomiya, Nariyoshi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Female
Gastric cancer
Gastric Mucosa - pathology
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori
Hepatocyte Growth Factor - metabolism
Humans
Kaplan-Meier Estimate
Male
MET
MET4 antibody
Middle Aged
Original
Prognosis
Proportional Hazards Models
Proto-Oncogene Proteins c-met - metabolism
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
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Summary:The role of HGF/SF‐MET signaling is important in cancer progression, but its relation with Helicobacter pylori‐positive gastric cancers remains to be elucidated. In total, 201 patients with primary gastric carcinoma who underwent curative or debulking resection without preoperative chemotherapy were studied. MET4 and anti‐HGF/SF mAbs were used for immunohistochemical analysis. Survival of gastric cancer patients was estimated by Kaplan–Meier method and compared with log‐rank. Cox proportional hazards models were fit to determine the independent association of MET‐staining status with outcome. The effect of live H. pylori bacteria on cell signaling and biological behaviors was evaluated using gastric cancer cell lines. MET4‐positive gastric cancers showed poorer prognosis than MET4‐negative cases (overall survival, P = 0.02; relapse‐free survival, P = 0.06). Positive staining for MET4 was also a statistically significant factor to predict poor prognosis in H. pylori‐positive cases (overall survival, P 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.13146