Diabetes consequences in the fetus liver of the non-obese diabetic mice

DM type 1 (T1D) incidence is increasing around 3% every year and represents risks for maternal and fetal health. The objective of this study was to explore the effects of diabetes on fetus liver cells in non-obese diabetic (NOD) mice. Hyperglycemic NOD (HNOD), normoglycemic NOD (NNOD) and BALB/c fem...

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Bibliographic Details
Published in:Nutrition & diabetes 2017-03, Vol.7 (3), p.e257-e257
Main Authors: Aires, M B, dos Santos, A C V, Kubrusly, M S, de Lima Luna, A C, D’Albuquerque, L A C, Maria, D A
Format: Article
Language:English
Subjects:
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Albumins - genetics
Albumins - metabolism
Animals
Clinical Nutrition
Diabetes
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - metabolism
Epidemiology
Female
Fetus
Gene Expression
Hepatocyte Nuclear Factor 4 - genetics
Hepatocyte Nuclear Factor 4 - metabolism
Hepatocytes - metabolism
Internal Medicine
Liver - metabolism
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Mice, Inbred NOD
MicroRNAs - genetics
MicroRNAs - metabolism
Short Communication
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Summary:DM type 1 (T1D) incidence is increasing around 3% every year and represents risks for maternal and fetal health. The objective of this study was to explore the effects of diabetes on fetus liver cells in non-obese diabetic (NOD) mice. Hyperglycemic NOD (HNOD), normoglycemic NOD (NNOD) and BALB/c females were used for mating, and the fetus livers were collected at 19.5 gestation day (gd). HNOD group had reduced fetal weight (989.5±68.32 vs 1290±57.39 mg BALB/c, P
ISSN:2044-4052
2044-4052
DOI:10.1038/nutd.2017.7