Effect of hypovolemia on traumatic spinal cord injury

Objectives: Experimentally evaluate the effect of hypovolemia in acute traumatic spinal cord injury. Methods: Twenty adult male Wistar rats were submitted to traumatic spinal cord injury through spinal cord contusion by direct impact. Ten animals were subjected to bleeding of 20% of their estimated...

Full description

Saved in:
Bibliographic Details
Published in:Spinal cord 2016-09, Vol.54 (9), p.742-745
Main Authors: de Cassia Sampaio, O, Defino, H L A, Del Bel Belluz Guimarães, E A
Format: Article
Language:English
Subjects:
631/378/1687/1825
631/378/1934
Anatomy
Animals
Biomedical and Life Sciences
Biomedicine
Disease Models, Animal
Human Physiology
Humans
Hypovolemia - etiology
Male
Motor Activity - physiology
Neurochemistry
Neuropsychology
Neurosciences
Original
original-article
Psychomotor Performance - physiology
Rats
Rats, Wistar
Spinal Cord Injuries - complications
Statistics, Nonparametric
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: Experimentally evaluate the effect of hypovolemia in acute traumatic spinal cord injury. Methods: Twenty adult male Wistar rats were submitted to traumatic spinal cord injury through spinal cord contusion by direct impact. Ten animals were subjected to bleeding of 20% of their estimated blood to simulate a hypovolemic condition after spinal cord contusion and 10 animals were used as control. The animals were evaluated before, 1, 3, 7 and 14 days after the production of the spinal cord injury through behavioral tests (inclined plane test and motor assessment). Results: The spinal cord contusion associated with hypovolemia had a negative influence on functional outcomes of the spinal cord injury. The animals submitted to hypovolemia after spinal cord contusion had lower scores in behavioral tests (inclined plane test and motor assessment), presenting a slower recovery of the motor function. Conclusion: In the experimental model used, the group of animals with hypovolemia after traumatic spinal cord injury had slower recovery and lower intensity in behavioral tests.
ISSN:1362-4393
1476-5624
DOI:10.1038/sc.2016.26