DG-CST (Disease Gene Conserved Sequence Tags), a database of human–mouse conserved elements associated to disease genes

The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequ...

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Bibliographic Details
Published in:Nucleic acids research 2005-01, Vol.33 (suppl-1), p.D505-D510
Main Authors: Boccia, Angelo, Petrillo, Mauro, di Bernardo, Diego, Guffanti, Alessandro, Mignone, Flavio, Confalonieri, Stefano, Luzi, Lucilla, Pesole, Graziano, Paolella, Giovanni, Ballabio, Andrea, Banfi, Sandro
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Computer Graphics
Conserved Sequence
Databases, Nucleic Acid
Genetic Predisposition to Disease
Genomics
Humans
Mice
User-Computer Interface
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Summary:The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human–mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gki011