Modest and Severe Maternal Iron Deficiency in Pregnancy are Associated with Fetal Anaemia and Organ-Specific Hypoxia in Rats

Prenatal iron-deficiency (ID) is known to alter fetal developmental trajectories, which predisposes the offspring to chronic disease in later life, although the underlying mechanisms remain unclear. Here, we sought to determine whether varying degrees of maternal anaemia could induce organ-specific...

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Bibliographic Details
Published in:Scientific reports 2017-04, Vol.7 (1), p.46573-46573, Article 46573
Main Authors: Woodman, Andrew G., Care, Alison S., Mansour, Yael, Cherak, Stephana J., Panahi, Sareh, Gragasin, Ferrante S., Bourque, Stephane L.
Format: Article
Language:English
Subjects:
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Anemia
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - embryology
Anemia, Iron-Deficiency - pathology
Animals
Blood flow
Brain - blood supply
Brain - embryology
Brain - pathology
Female
Fetal Diseases - blood
Fetuses
Hemoglobin
Humanities and Social Sciences
Hypoxia
Iron
Iron - deficiency
multidisciplinary
Nutrient deficiency
Offspring
Placenta - blood supply
Placenta - embryology
Placenta - pathology
Pregnancy
Rats
Rats, Sprague-Dawley
Rodents
Science
Ultrasound
Uterus
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Summary:Prenatal iron-deficiency (ID) is known to alter fetal developmental trajectories, which predisposes the offspring to chronic disease in later life, although the underlying mechanisms remain unclear. Here, we sought to determine whether varying degrees of maternal anaemia could induce organ-specific patterns of hypoxia in the fetuses. Pregnant female Sprague Dawley rats were fed iron-restricted or iron-replete diets to induce a state of moderate (M-ID) or severe ID (S-ID) alongside respective controls. Ultrasound biomicroscopy was performed on gestational day (GD)20 to assess uterine and umbilical artery blood flow patterns. On GD21, tissues were collected and assessed for hypoxia using pimonidazole staining. Compared to controls, maternal haemoglobin (Hb) in M- and S-ID were reduced 17% (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep46573