Comparison of voluntary and reflex cough effectiveness in Parkinson's disease

• Published in: Parkinsonism & related disorders 2014-11, Vol.20 (11), p.1226-1230
• Main Authors: Wheeler Hegland, Karen, Troche, Michelle S, Brandimore, Alexandra E, Davenport, Paul W, Okun, Michael S
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Airway protection; Cough; Cough - complications; Cough - physiopathology; Deglutition - physiology; Deglutition Disorders - physiopathology; Female; Humans; Male; Middle Aged; Neurology; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson's disease; Peak Expiratory Flow Rate - physiology; Reflex - physiology; Reflex cough; Voluntary cough
• ISSN: 1353-8020; 1873-5126
• DOI: 10.1016/j.parkreldis.2014.09.010

Abstract Introduction Multiple airway protective mechanisms are impacted with Parkinson's disease (PD), including swallowing and cough. Cough serves to eject material from the lower airways, and can be produced voluntarily (on command) and reflexively in response to aspirate material or other airway irritants. Voluntary cough effectiveness is reduced in PD however it is not known whether reflex cough is affected as well. The goal of this study was to compare the effectiveness between voluntary and reflex cough in patients with idiopathic PD. Methods Twenty patients with idiopathic PD participated. Cough airflow data were recorded via facemask in line with a pneumotachograph. A side delivery port connected the nebulizer for delivery of capsaicin, which was used to induce cough. Three voluntary coughs and three reflex coughs were analyzed from each participant. A two-way repeated measures analysis of variance was used to compare voluntary versus reflex cough airflow parameters. Results Significant differences were found for peak expiratory flow rate (PEFR) and cough expired volume (CEV) between voluntary and reflex cough. Specifically, both PEFR and CEV were reduced for reflex as compared to voluntary cough. Conclusion Cough PEFR and CEV are indicative of cough effectiveness in terms of the ability to remove material from the lower airways. Differences between these two cough types likely reflect differences in the coordination of the respiratory and laryngeal subsystems. Clinicians should be aware that evaluation of cough function using voluntary cough tasks overestimates the PEFR and CEV that would be achieved during reflex cough in patients with PD.