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Activity-dependent increases in [Ca 2+ ] i contribute to digital-analog plasticity at a molluscan synapse
In a type of short-term plasticity that is observed in a number of systems, synaptic transmission is potentiated by depolarizing changes in the membrane potential of the presynaptic neuron before spike initiation. This digital-analog form of plasticity is graded. The more depolarized the neuron, the...
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Published in: | Journal of neurophysiology 2017-06, Vol.117 (6), p.2104-2112 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In a type of short-term plasticity that is observed in a number of systems, synaptic transmission is potentiated by depolarizing changes in the membrane potential of the presynaptic neuron before spike initiation. This digital-analog form of plasticity is graded. The more depolarized the neuron, the greater the increase in the efficacy of synaptic transmission. In a number of systems, including the system presently under investigation, this type of modulation is calcium dependent, and its graded nature is presumably a consequence of a direct relationship between the intracellular calcium concentration ([Ca
]
) and the effect on synaptic transmission. It is therefore of interest to identify factors that determine the magnitude of this type of calcium signal. We studied a synapse in
and demonstrate that there can be a contribution from currents activated during spiking. When neurons spike, there are localized increases in [Ca
]
that directly trigger neurotransmitter release. Additionally, spiking can lead to global increases in [Ca
]
that are reminiscent of those induced by subthreshold depolarization. We demonstrate that these spike-induced increases in [Ca
]
result from the activation of a current not activated by subthreshold depolarization. Importantly, they decay with a relatively slow time constant. Consequently, with repeated spiking, even at a low frequency, they readily summate to become larger than increases in [Ca
]
induced by subthreshold depolarization alone. When this occurs, global increases in [Ca
]
induced by spiking play the predominant role in determining the efficacy of synaptic transmission.
We demonstrate that spiking can induce global increases in the intracellular calcium concentration ([Ca
]
) that decay with a relatively long time constant. Consequently, summation of the calcium signal occurs even at low firing frequencies. As a result there is significant, persistent potentiation of synaptic transmission. |
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ISSN: | 0022-3077 1522-1598 |
DOI: | 10.1152/jn.00034.2017 |