Chronic intermittent ethanol exposure leads to alterations in brain-derived neurotrophic factor within the frontal cortex and impaired behavioral flexibility in both adolescent and adult rats

Highlights • Chronic intermittent exposure to ethanol transiently alter prefrontal cortical Brain Derived Neurotrophic Factor levels. • Adults exposed to chronic intermittent ethanol display impairments in discrimination and reversal learning. • Early and mid adolescent animals exposed to chronic in...

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Bibliographic Details
Published in:Neuroscience 2017-04, Vol.348, p.324-334
Main Authors: Fernandez, Gina M, Lew, Brandon J, Vedder, Lindsey C, Savage, Lisa M
Format: Article
Language:English
Subjects:
adult
Age Factors
Animals
Behavior, Animal - drug effects
Brain-Derived Neurotrophic Factor - metabolism
chronic intermittent ethanol exposure
discrimination learning
Discrimination Learning - drug effects
early adolescence
Ethanol - administration & dosage
Frontal Lobe - drug effects
Frontal Lobe - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
mid-adolescence
Neurology
Rats
Rats, Sprague-Dawley
reversal learning
Reversal Learning - drug effects
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Summary:Highlights • Chronic intermittent exposure to ethanol transiently alter prefrontal cortical Brain Derived Neurotrophic Factor levels. • Adults exposed to chronic intermittent ethanol display impairments in discrimination and reversal learning. • Early and mid adolescent animals exposed to chronic intermittent ethanol only display impairments during reversal learning.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.02.045