Association between the TACC3 rs798766 Polymorphism and Risk of Urinary Bladder Cancer: A Synthesis Based on Current Evidence

• Published in: Disease markers 2017-01, Vol.2017 (2017), p.1-6
• Main Authors: Hu, Bang-Wang, Liao, Yi, Chen, Jia-Feng, Shi, Ming-Jun, Meng, Xiangyu, Hireche, Ahmed
• Format: Article
• Language: English
• Subjects: Asian Continental Ancestry Group - genetics; Bladder; Bladder cancer; Cancer; Data processing; Ethnicity; European Continental Ancestry Group - genetics; Female; Genetic aspects; Genetic markers; Health aspects; Health risk assessment; Health risks; Humans; Male; Microtubule-Associated Proteins - genetics; Minority & ethnic groups; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Review; Risk factors; Risk management; Scientific papers; Search engines; Single nucleotide polymorphisms; Subgroups; Synthesis; Urinary bladder; Urinary Bladder Neoplasms - ethnology; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2017/7850708

Background. A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. Methods. EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. “rs798766” and “urinary bladder cancer” were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated. Meta-analysis was performed using extracted data. Subgroup analysis by ethnicity was also performed. Population attributable risk (PAR) was calculated. Results. We found a significant association between rs798766[T] and increased risk of bladder cancer, allelic[T] OR=1.27, 95%CI=1.20–1.33. Subgroup analysis by ethnicity revealed similar results, allelic[T] OR=1.24, 95%CI=1.17–1.32 in Caucasian subjects and allelic[T] OR=1.33, 95%CI=1.21–1.46 in Asian subjects. PAR based on pooled allelic ORs and the frequency of the risk allele in control subjects was 4.63% in the overall population and 3.92% in Asians and 4.36% in Caucasians. Conclusion. rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.