Folate-mediated chemotherapy and diagnostics: An updated review and outlook

Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applicatio...

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Bibliographic Details
Published in:Journal of controlled release 2017-04, Vol.252, p.73-82
Main Authors: Xu, Leyuan, Bai, Qianming, Zhang, Xin, Yang, Hu
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Diagnosis
Drug Delivery Systems
Drug Liberation
Folate receptor
Folate Receptors, GPI-Anchored - metabolism
Folic acid
Folic Acid - chemistry
Folic Acid - metabolism
Humans
Molecular Probes - administration & dosage
Molecular Targeted Therapy
Nanomedicine
Nanoparticles - chemistry
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Targeted delivery
Theranostic Nanomedicine
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Description
Summary:Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2017.02.023