Hide and seek: the secret identity of the phosphatidylserine receptor

Phosphatidylserine on the dying cell surface helps identify apoptotic cells to phagocytes, which then engulf them. A candidate phagocyte receptor for phosphatidylserine was identified using phage display, but the phenotypes of knockout mice lacking this presumptive receptor, as well as the location...

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Bibliographic Details
Published in:Journal of biology (London, England) England), 2004, Vol.3 (4), p.14-14
Main Authors: Williamson, Patrick, Schlegel, Robert A
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Gene Deletion
Mice
Mice, Knockout
Minireview
Receptors, Cell Surface - analysis
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
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Summary:Phosphatidylserine on the dying cell surface helps identify apoptotic cells to phagocytes, which then engulf them. A candidate phagocyte receptor for phosphatidylserine was identified using phage display, but the phenotypes of knockout mice lacking this presumptive receptor, as well as the location of the protein within cells, cast doubt on the assignment of this protein as the phosphatidylserine receptor.
ISSN:1478-5854
1475-4924
DOI:10.1186/jbiol14