Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System

Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applic...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-17
Main Authors: Kohen, Ron, Bitton, Ronit, Ben Sasson, Shmuel, Soroka, Yoram, Frušić-Zlotkin, Marina, Ben Yehuda Greenwald, Maya, Bianco-Peled, Havazelet
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Bioavailability
Cancer
Cell Line, Transformed
Chemical engineering
Chronic illnesses
Colleges & universities
Complications and side effects
Curcumin - chemistry
Curcumin - pharmacology
Cytotoxicity
Dehydrogenases
Dermatitis
Drug Delivery Systems - methods
Emulsions
Enzymes
Genetic aspects
Health aspects
Homeostasis
Humans
Kelch-Like ECH-Associated Protein 1 - metabolism
Keratinocytes - metabolism
Keratinocytes - pathology
Medical research
NF-E2-Related Factor 2 - metabolism
Oxidative stress
Psoriasis
Rodents
Skin
Skin Aging - drug effects
Skin Aging - radiation effects
Stress (Physiology)
Transcription factors
Turmeric
Ultraviolet radiation
Ultraviolet Rays - adverse effects
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Summary:Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies. These limitations can be overcome by using a nanotechnology-based delivery system. Here, we elucidated the possibility of using curcumin encapsulated in a microemulsion preserving its unique chemical structure. We also examined whether curcumin microemulsion would reduce UVB-induced toxicity in skin. A significant curcumin concentration was found in the human skin dermis following topical application of a curcumin microemulsion. Moreover, curcumin microemulsion enhanced the reduction of UV-induced cytotoxicity in epidermal cells, paving the way for other incorporated electrophiles in encapsulated form protecting skin against stress-related diseases.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/5205471