A myocardial lineage derives from Tbx18 epicardial cells

Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we repo...

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Bibliographic Details
Published in:Nature 2008-07, Vol.454 (7200), p.104-108
Main Authors: Evans, Sylvia M, Cai, Chen-Leng, Martin, Jody C, Sun, Yunfu, Cui, Li, Wang, Lianchun, Ouyang, Kunfu, Yang, Lei, Bu, Lei, Liang, Xingqun, Zhang, Xiaoxue, Stallcup, William B, Denton, Christopher P, McCulloch, Andrew, Chen, Ju
Format: Article
Language:English
Subjects:
Analysis
Animals
Biological and medical sciences
Cardiovascular diseases
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell Lineage
Cell physiology
Cells
Coronary vessels
Development and progression
Forecasts and trends
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Genetic aspects
Heart
Heart - growth & development
Heart cells
Humanities and Social Sciences
Identification and classification
Lac Operon - genetics
letter
Mice
Molecular and cellular biology
multidisciplinary
Myocardial diseases
Myocardium - cytology
Myocardium - metabolism
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Myocytes, Smooth Muscle - metabolism
Pericardium - cytology
Pericardium - metabolism
Regenerative medicine
Science
Science (multidisciplinary)
Stem cells
Stem Cells - cytology
Stem Cells - metabolism
T-Box Domain Proteins - genetics
T-Box Domain Proteins - metabolism
Transcription factors
Varieties
Citations: Items that this one cites
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Summary:Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature06969