Investigating the Association of Genetic Admixture and Donor/Recipient Genetic Disparity with Transplant Outcomes

Highlights • This is the first study to address the effect of genetic ancestry on HCT outcome, as opposed to self-identified race/ethnicity. • Higher African genetic admixture in recipients and donors was associated with lower Overall Survival and Disease-Free Survival and increased Transplant-Relat...

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Published in:Biology of blood and marrow transplantation 2017-06, Vol.23 (6), p.1029-1037
Main Authors: Madbouly, Abeer, PhD, Wang, Tao, PhD, Haagenson, Michael, MS, Paunic, Vanja, PhD, Vierra-Green, Cynthia, MS, Fleischhauer, Katharina, MD, Hsu, Katharine C., MD, PhD, Verneris, Michael R., MD, Majhail, Navneet S., MD, Lee, Stephanie J., MD, MPH, Spellman, Stephen R., MBS, Maiers, Martin, MS
Format: Article
Language:English
Subjects:
Adult
African-American race
Ancestry informative markers
Female
Genetic admixture
Genetic ancestry
Genetic Variation
Healthcare Disparities - ethnology
Hematology, Oncology and Palliative Medicine
Hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - ethnology
Hematopoietic Stem Cell Transplantation - mortality
Humans
Male
Middle Aged
Race and ethnicity
Transplantation, Homologous
Treatment Outcome
Unrelated Donors
Young Adult
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Summary:Highlights • This is the first study to address the effect of genetic ancestry on HCT outcome, as opposed to self-identified race/ethnicity. • Higher African genetic admixture in recipients and donors was associated with lower Overall Survival and Disease-Free Survival and increased Transplant-Related Mortality (TRM). • Our findings were not associated with significant increase in GVHD or relapse, suggesting that the main driver is potentially TRM, not related to GVHD, which occurred 6-12 months after transplant. • While the findings are statistically significant, higher number are needed to validate our study findings.
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2017.02.019