Associations of gender and a proxy of female menopausal status with histological features of drug‐induced liver injury

Background & Aim Gender and menopause may contribute to type and severity of drug‐induced liver injury (DILI) by influencing host responses to injury. The aim of this study was to assess the associations of gender and female age 50 [a proxy of menopause] with histological features of liver injur...

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Bibliographic Details
Published in:Liver international 2017-11, Vol.37 (11), p.1723-1730
Main Authors: Suzuki, Ayako, Barnhart, Huiman, Gu, Jiezhun, Bonkovsky, Herbert L., Tillmann, Hans L., Fontana, Robert J., Kleiner, David E.
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Aged
Aging (artificial)
Amoxicillin
Apoptosis
Biopsy
Chemical and Drug Induced Liver Injury - classification
Chemical and Drug Induced Liver Injury - pathology
Cholestasis
Cholestasis - chemically induced
Cholestasis - pathology
Clavulanic acid
Cohort Studies
Cross-Sectional Studies
drug‐induced liver injury
Female
Gender
gender difference
Hepatitis
Hepatocytes
hepatotoxicity
Humans
Infiltration
Injuries
Iron
Liver
Liver diseases
liver histology
Logistic Models
Male
Men
Menopause
Middle Aged
Nitrofurantoin
Sex Factors
Steroid hormones
Steroids
Women
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Summary:Background & Aim Gender and menopause may contribute to type and severity of drug‐induced liver injury (DILI) by influencing host responses to injury. The aim of this study was to assess the associations of gender and female age 50 [a proxy of menopause] with histological features of liver injury in 212 adults enrolled in the Drug‐Induced Liver Injury Network (DILIN) registry. Methods All participants had a causality score of at least ‘probable’, a liver biopsy within 30 days of DILI onset, and no prior chronic liver disease. Biochemical and histological injury types were classified as hepatocellular or cholestatic/mixed injury. The cohort was divided into three gender/age categories: men (41.0%), women
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13380