Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis

Background and Aims. Plenty of studies were conducted to explore the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer with contradictory results. This study aims to summarize the prognostic significance of NLR in patients with ovarian cancer. Methods. A literature se...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-7
Main Authors: Zhao, Yongzhao, Fathy, Abdel Hamid, Cheng, Sijin, Yan, Guangyue, Zhang, Liu, Chen, Shubo, Yan, Nana
Format: Article
Language:English
Subjects:
Bioindicators
Biological markers
Biomarkers
Biomarkers, Tumor - blood
Cancer
Cancer patients
Cancer therapies
Care and treatment
Chemotherapy
Comparative analysis
Female
Health aspects
Humans
Leukocyte Count
Libraries
Lung cancer
Lymphatic system
Lymphocytes
Lymphocytes - pathology
Medical prognosis
Meta-analysis
Metastasis
Multivariate analysis
Neutrophils
Neutrophils - pathology
Oncology
Ovarian cancer
Ovarian Neoplasms - blood
Ovarian Neoplasms - pathology
Patients
Prognosis
Proportional Hazards Models
Review
Studies
Survival
Survival analysis
Tumors
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Summary:Background and Aims. Plenty of studies were conducted to explore the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer with contradictory results. This study aims to summarize the prognostic significance of NLR in patients with ovarian cancer. Methods. A literature search in PubMed, Cochrane Library, and Embase was conducted. The endpoints were progression-free survival (PFS) and overall survival (OS). Results. Eleven studies involving a total of 2,892 patients were identified. The results indicated that patients with high NLR had shorter PFS compared to patients with low NLR in ovarian cancer (HR = 1.55, 95% CI = 1.15–2.08, p=0.004, and I2=61%). Similarly, high NLR was related to shorter OS (HR = 1.51, 95% CI = 1.03–2.23, p=0.04, and I2=85%). Moreover, high NLR was significantly associated with shorter PFS when the NLR cut-off was less than 3.3 (p=0.03) or when treatment is operation (p=0.002). In addition, high NLR was distinctly related to worse OS in Asian people (p = 0.04) or operation (p = 0.04). Conclusion. High NLR was associated with shorter PFS and shorter OS in ovarian cancer. NLR is potentially a promising prognostic biomarker in patients with ovarian cancer.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/7943467