Depression and ART Initiation Among HIV Serodiscordant Couples in Kenya and Uganda

Depression is a known barrier for antiretroviral therapy (ART) adherence, but less is understood about its effects on ART initiation. We followed 1013 HIV-infected individuals participating in the Partners Demonstration Project, an open-label study of integrated pre-exposure prophylaxis (PrEP) and A...

Full description

Saved in:
Bibliographic Details
Published in:AIDS and behavior 2017-08, Vol.21 (8), p.2509-2518
Main Authors: Velloza, Jennifer, Celum, Connie, Haberer, Jessica E., Ngure, Kenneth, Irungu, Elizabeth, Mugo, Nelly, Baeten, Jared M., Heffron, Renee
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral Therapy, Highly Active
CD4 antigen
CD4 Lymphocyte Count
Constraints
Couples
Depression - psychology
Female
Hazard assessment
Health Psychology
Health risk assessment
HIV
HIV Infections - drug therapy
HIV Infections - prevention & control
HIV Infections - psychology
Human immunodeficiency virus
Humans
Infectious Diseases
Kenya
Male
Medication Adherence - psychology
Medicine
Medicine & Public Health
Mental depression
Original Paper
Pre-Exposure Prophylaxis
Prescription drugs
Prophylaxis
Public Health
Sexual Partners - psychology
Symptoms
Uganda
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Depression is a known barrier for antiretroviral therapy (ART) adherence, but less is understood about its effects on ART initiation. We followed 1013 HIV-infected individuals participating in the Partners Demonstration Project, an open-label study of integrated pre-exposure prophylaxis (PrEP) and ART delivery for HIV serodiscordant couples in Kenya and Uganda. Associations between depression, measured annually with the Hopkins Symptoms Checklist-Depression (HSCL-D), and ART initiation were assessed with Cox proportional hazards regression. At enrollment, 162 participants (16.0%) reported symptoms consistent with probable depression, defined by a HSCL-D mean score >1.75, and this proportion decreased during study follow-up (6.7 and 3.6% at 12- and 24-months, respectively; p value 
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-017-1829-z