Methods for studying the metabolic basis of Drosophila development

The field of metabolic research has experienced an unexpected renaissance. While this renewed interest in metabolism largely originated in response to the global increase in diabetes and obesity, studies of metabolic regulation now represent the frontier of many biomedical fields. This trend is espe...

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Published in:Wiley interdisciplinary reviews. Developmental biology 2017-09, Vol.6 (5), p.e280-n/a
Main Authors: Li, Hongde, Tennessen, Jason M.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - genetics
Cell Differentiation - physiology
Developmental Biology
Diabetes mellitus
Drosophila
Drosophila melanogaster
Gene Expression Regulation, Developmental - genetics
Gene Expression Regulation, Developmental - physiology
Insects
Metabolism
Signal Transduction - genetics
Signal Transduction - physiology
Stem cells
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Summary:The field of metabolic research has experienced an unexpected renaissance. While this renewed interest in metabolism largely originated in response to the global increase in diabetes and obesity, studies of metabolic regulation now represent the frontier of many biomedical fields. This trend is especially apparent in developmental biology, where metabolism influences processes ranging from stem cell differentiation and tissue growth to sexual maturation and reproduction. In this regard, the fruit fly Drosophila melanogaster has emerged as a powerful tool for dissecting conserved mechanisms that underlie developmental metabolism, often with a level of detail that is simply not possible in other animals. Here we describe why the fly is an ideal system for exploring the relationship between metabolism and development, and outline a basic experimental strategy for conducting these studies. WIREs Dev Biol 2017, 6:e280. doi: 10.1002/wdev.280 This article is categorized under: Technologies > Analysis of Cell, Tissue, and Animal Phenotypes Drosophila development progresses through four easily recognized life stages. Metabolism adapts to the energetic and biosynthetic demands of each developmental stage. Several methods are available for studying developmental metabolism in Drosophila.
ISSN:1759-7684
1759-7692
DOI:10.1002/wdev.280