Clinical Significance of INHBA Gene Expression in Patients with Gastric Cancer who Receive Curative Resection Followed by Adjuvant S-1 Chemotherapy

Standard treatment for stage II/III gastric cancer is curative resection followed by adjuvant chemotherapy. However, the five-year survival remains unsatisfactory. Inhibin βA (INHBA) has been reported to be associated with cancer cell proliferation and chemoresistance. We studied the clinical signif...

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Bibliographic Details
Published in:In vivo (Athens) 2017-07, Vol.31 (4), p.565-571
Main Authors: Katayama, Yusuke, Oshima, Takashi, Sakamaki, Kentaro, Aoyama, Toru, Sato, Tsutomu, Masudo, Katsuhiko, Shiozawa, Manabu, Yoshikawa, Takaki, Rino, Yasushi, Imada, Toshio, Masuda, Munetaka
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - genetics
Cell Proliferation - drug effects
Chemotherapy, Adjuvant
Disease-Free Survival
Drug Combinations
Female
Gene Expression Regulation, Neoplastic - drug effects
Humans
Inhibin-beta Subunits - genetics
Male
Middle Aged
Neoplasm Staging
Oxonic Acid - administration & dosage
Prognosis
Real-Time Polymerase Chain Reaction
Stomach Neoplasms - drug therapy
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Tegafur - administration & dosage
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Summary:Standard treatment for stage II/III gastric cancer is curative resection followed by adjuvant chemotherapy. However, the five-year survival remains unsatisfactory. Inhibin βA (INHBA) has been reported to be associated with cancer cell proliferation and chemoresistance. We studied the clinical significance of INHBA gene expression in 134 patients with stage II/III gastric cancer who received adjuvant chemotherapy with S-1. INHBA expression of specimens of cancer tissue and adjacent normal mucosa was measured by quantitative real-time, reverse-transcription polymerase chain reaction (RT-PCR). INHBA expression levels were significantly higher in cancer tissue than in adjacent normal mucosa. High INHBA expression was associated with significantly poorer 5-year survival than was low expression. On multivariate analysis, INHBA expression was an independent prognostic factor. INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
ISSN:1791-7549
0258-851X
1791-7549
DOI:10.21873/invivo.11095