Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

Sepsis induced loss of muscle mass and function contributes to promote physical inactivity and disability in patients. In this experimental study, mice were sacrificed 1, 4, or 7 days after cecal ligation and puncture (CLP) or sham surgery. When compared with diaphragm, locomotor muscles were more p...

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Published in:Scientific reports 2017-09, Vol.7 (1), p.10866-12, Article 10866
Main Authors: Morel, Jérome, Palao, Jean-Charles, Castells, Josiane, Desgeorges, Marine, Busso, Thierry, Molliex, Serge, Jahnke, Vanessa, Del Carmine, Peggy, Gondin, Julien, Arnould, David, Durieux, Anne Cécile, Freyssenet, Damien
Format: Article
Language:English
Subjects:
692/420/254
692/700/459
AKT protein
Atrophy
Cecum
Diaphragm
Gastrocnemius muscle
Human health and pathology
Humanities and Social Sciences
Infectious diseases
Life Sciences
multidisciplinary
Muscle contraction
Muscles
Myostatin
Phagocytosis
Proteasomes
Rodents
Science
Science (multidisciplinary)
Sepsis
Surgery
Tissues and Organs
TOR protein
Ubiquitin
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Summary:Sepsis induced loss of muscle mass and function contributes to promote physical inactivity and disability in patients. In this experimental study, mice were sacrificed 1, 4, or 7 days after cecal ligation and puncture (CLP) or sham surgery. When compared with diaphragm, locomotor muscles were more prone to sepsis-induced muscle mass loss. This could be attributed to a greater activation of ubiquitin-proteasome system and an increased myostatin expression. Thus, this study strongly suggests that the contractile activity pattern of diaphragm muscle confers resistance to atrophy compared to the locomotor gastrocnemius muscle. These data also suggest that a strategy aimed at preventing the activation of catabolic pathways and preserving spontaneous activity would be of interest for the treatment of patients with sepsis-induced neuromyopathy.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-11440-5