Second-generation drug-eluting stents in the elderly patients with acute coronary syndrome: the in-hospital and 12-month follow-up of the all-comer registry

• Published in: Aging clinical and experimental research 2017-10, Vol.29 (5), p.885-893
• Main Authors: Wańha, Wojciech, Kawecki, Damian, Roleder, Tomasz, Morawiec, Beata, Gładysz, Sylwia, Kowalówka, Adam, Jadczyk, Tomasz, Adamus, Barbara, Pawłowski, Tomasz, Smolka, Grzegorz, Kaźmierski, Maciej, Ochała, Andrzej, Nowalany-Kozielska, Ewa, Wojakowski, Wojciech
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - therapy; Acute coronary syndromes; Aged; Blood transfusions; Cardiovascular disease; Coronary Angiography; Coronary Artery Disease - epidemiology; Drug-Eluting Stents; Female; Follow-Up Studies; Geriatrics/Gerontology; Hospitals; Humans; Male; Medicine; Medicine & Public Health; Older people; Original; Original Article; Patients; Percutaneous Coronary Intervention - adverse effects; Percutaneous Coronary Intervention - methods; Registries; Stents; Stroke - epidemiology; Stroke - etiology; Thrombosis - epidemiology; Treatment Outcome
• ISSN: 1720-8319; 1594-0667; 1720-8319
• DOI: 10.1007/s40520-016-0649-8

Background Katowice–Zabrze registry provides data that can be used to evaluate clinical outcomes of percutaneous coronary interventions in elderly patients (≥70 y/o) treated with either first- (DES-I) or second-generation (DES-II) drug-eluting stents (DES). Methods The registry consisted of data from 1916 patients treated with coronary interventions using either DES-I or DES-II stents. For our study, we defined patients ≥70 years of age as elderly. We evaluated any major adverse cardiac and cerebral events (MACCE) at 12-month follow-up. Results Coronary angiography revealed a higher incidence of multivessel coronary artery disease in this elderly patient population. There were no differences in acute and subacute stent thrombosis (0.4 vs. 0.6%, p  = 0.760; 0.4 vs. 0.4%; p  = 0.712). Elderly patients experienced more in-hospital bleeding complications requiring blood transfusion (2.0 vs. 0.9%; p  = 0.003). Resuscitated cardiac arrests (2.0 vs. 0.9%; p  = 0.084) were observed more often in this elderly patients during hospitalization. The composite in-hospital MACCE rates did not differ statistically between both groups (1.4 vs. 1.1%; p  = 0.567). Data from a twelve-month follow-up disclosed that mortality was higher (7.1 vs. 1.8%; p