The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

BACKGROUND Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. MATERIAL AND METHODS The study included 21 adult patients with a diagn...

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Bibliographic Details
Published in:Medical science monitor 2017-09, Vol.23, p.4278-4283
Main Authors: Serbest, Sancar, Tiftikçi, Uğur, Tosun, Hacı Bayram, Kısa, Üçler
Format: Article
Language:English
Subjects:
Adult
Bone and Bones - metabolism
Bone and Bones - physiology
Bony Callus - metabolism
Clinical Research
Female
Femoral Neck Fractures - surgery
Femur - surgery
Femur Head - surgery
Fibronectins - analysis
Fibronectins - metabolism
Fibronectins - physiology
Fracture Healing - physiology
Humans
Male
Tibia - surgery
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Summary:BACKGROUND Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. MATERIAL AND METHODS The study included 21 adult patients with a diagnosed fracture of the lower extremity (femur or tibia). Informed consent was obtained from all the patients. A total of four venous blood samples were taken from the patients: before fracture stabilization, then postoperatively on days 1, 10, and 60. In patients with femoral neck fracture who had hip prosthesis applied, bone tissue samples were taken from the removed femur head and irisin was determined immunohistochemically in muscle biopsies taken from the same patients. RESULTS In analysis, it was revealed that the mean value of irisin 60 days after operation is significantly higher than the values of irisin before operation, 1 day after operation, and 15 day after operation (p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.906293