Microbially derived biosensors for diagnosis, monitoring and epidemiology

Summary Living cells have evolved to detect and process various signals and can self‐replicate, presenting an attractive platform for engineering scalable and affordable biosensing devices. Microbes are perfect candidates: they are inexpensive and easy to manipulate and store. Recent advances in syn...

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Bibliographic Details
Published in:Microbial biotechnology 2017-09, Vol.10 (5), p.1031-1035
Main Authors: Chang, Hung‐Ju, Voyvodic, Peter L., Zúñiga, Ana, Bonnet, Jérôme
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Biomarkers
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Biosensors
Deoxyribonucleic acid
Design specifications
DNA
DNA damage
DNA methylation
DNA repair
E coli
Engineering
Environmental monitoring
Environmental Monitoring - instrumentation
Environmental Monitoring - methods
Epidemiologic Methods
Epidemiology
Epidemiology - instrumentation
Food
Genetic engineering
Goal 3. Ensure healthy lives and promote well‐being for all at all ages
Humans
Ligands
Microorganisms
PCB
Pollutants
Polychlorinated biphenyls
Signal processing
Synthetic biology
Urine
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Summary:Summary Living cells have evolved to detect and process various signals and can self‐replicate, presenting an attractive platform for engineering scalable and affordable biosensing devices. Microbes are perfect candidates: they are inexpensive and easy to manipulate and store. Recent advances in synthetic biology promise to streamline the engineering of microbial biosensors with unprecedented capabilities. Here we review the applications of microbially‐derived biosensors with a focus on environmental monitoring and healthcare applications. We also identify critical challenges that need to be addressed in order to translate the potential of synthetic microbial biosensors into large‐scale, real‐world applications. Living cells have evolved to detect and process various signals and can self‐replicate, presenting an attractive platform for engineering scalable and affordable biosensing devices. Here we review the applications of microbial‐derived biosensors to environmental monitoring and healthcare applications. We also discuss the challenges to address in order to accelerate the transition of these technologies into real‐world applications.
ISSN:1751-7915
1751-7915
DOI:10.1111/1751-7915.12791